Hormones, Migraines, and Women's Health: A Lifelong Connection

Hormonal fluctuations shape women's health across every stage of life, influencing everything from mood and metabolism to migraine frequency and severity. For many women, migraine attacks are not just an occasional headache—they stem from a recurring, debilitating neurological condition and are closely tied to hormonal changes.
Before puberty, boys and girls experience migraine at roughly equal rates. However, after puberty, when estrogen levels begin to rise, migraine prevalence in females increases dramatically. Research shows that women are disproportionately affected by migraine, experiencing migraine attacks at a rate approximately three times higher than men. About 18% of women and 6% of men suffer from migraine annually, while over a lifetime, 43% of women and 18% of men report having experienced migraine attacks. This disparity is even more pronounced in certain populations, such as in Italy, where 32.9% of women and 13.0% of men are affected by migraine.
These differences are largely driven by hormonal fluctuations, particularly involving estrogen, but also by differences in brain structure, genetic polymorphisms, and neuronal pathways. This makes understanding hormonal influences on migraine crucial for effective treatment and prevention strategies.
What You’ll Learn in This Series
- The Science Behind Menstrual Migraine: How estrogen fluctuations trigger migraine attacks and why some women experience severe headaches before, during, or after their periods.
- Pregnancy and Postpartum Headaches: Why some women find relief from migraine attacks during pregnancy, while others experience worsening symptoms postpartum.
- The Role of Magnesium, Supplements, and Medications: Exploring evidence-based treatments that can help prevent or manage hormonal migraine attacks.
- Menopause and Migraine: Why migraine attacks can worsen during perimenopause but improve post-menopause, and what strategies can help during the transition.
- Medication and Hormonal Therapies: Understanding the risks and benefits of birth control, hormone replacement therapy (HRT), and other treatments for migraine prevention.
- Safe and Effective Migraine Management at Different Life Stages: Practical, expert-backed strategies to minimize migraine attacks and improve quality of life.
Hormonal Changes and Migraine Risk by Age

Life Stage
Understanding these gender-specific migraine patterns is key to finding the right strategies for prevention and treatment. Before puberty, boys and girls experience migraine at the same rate, but after puberty, women’s migraine attacks become far more frequent and severe due to hormonal cycles. While men’s migraine attacks tend to be more consistent over time, women’s attacks are heavily influenced by hormonal fluctuations, making them more severe, frequent, and harder to predict at different life stages.
Women’s migraine attacks are often dismissed as just a normal part of life, but research shows that recognizing hormonal influences can lead to better treatment and relief. This series will provide the insights and tools needed to navigate migraine with confidence and take control of your health.
Stay Tuned for Expert Advice
Each article in this series will break down the complex relationship between hormones and migraine, offering practical strategies for managing headaches at every stage of life. Whether you're struggling with menstrual migraine, navigating pregnancy, or looking for relief during menopause, we’re here to help.
Disclaimer
This article is for informational purposes only and should not be considered medical advice. If you experience menstrual migraine attacks or other severe headaches, consult your healthcare provider for a proper diagnosis and treatment plan. To explore treatment options, consider booking an appointment with Haven Headache for expert guidance and personalized care.