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Safe Migraine Treatments During Pregnancy: A Guide for Expecting Moms

Safe Migraine Treatments During Pregnancy: A Guide for Expecting Moms

Dr. Susan Hutchinson
March 10, 2025
5
min read

Pregnancy is an exciting journey, but for those who suffer from migraine attacks, it can also create uncertainty. Many women worry about how pregnancy will impact their migraine symptoms and what treatments are safe. The good news is that most women with migraines—especially those without aura—experience an improvement in symptoms during pregnancy. However, for those who continue to have attacks, there are safe and effective treatment options available.

Why Migraine Attacks Can Change During Pregnancy

Hormonal shifts play a significant role in migraine patterns. During pregnancy, estrogen levels rise and stabilize, often leading to a reduction in migraine frequency, particularly in the second and third trimesters. However, some women may still experience migraine attacks, especially in the first trimester when hormonal fluctuations are more pronounced..

Safe Medications for Migraine Relief

If you experience migraine attacks during pregnancy, it's crucial to collaborate with a healthcare provider to explore safe treatment options. Here are some medications that are considered safe for use during pregnancy:

1. Acetaminophen (Tylenol)

  • Considered the safest pain reliever during pregnancy.
  • Can be taken alone or with small amounts of caffeine for enhanced relief.

2. Triptans

  • Sumatriptan (Imitrex), Rizatriptan (Maxalt), and Naratriptan (Amerge) are the most studied and deemed safe.
  • Can be used in the same manner as before pregnancy if prescribed by a health care provider.

3. Anti-Nausea Medication

  • Metoclopramide (Reglan)) can help with both nausea and migraine symptoms.
  • Available in oral and injectable forms for convenience.

4. Diphenhydramine (Benadryl)

  • Often thought of as just a sedative, but it has been shown to have direct benefits for migraine relief.
  • Can be taken alone or combined with other safe treatments.

5. Nerve Blocks

  • In-office procedures using lidocaine or other numbing agents to temporarily relieve migraine symptoms.
  • A great non-medication option for those seeking relief without systemic medications.

Medications to Avoid During Pregnancy

Some medications pose risks to fetal development and should be avoided:

  • NSAIDs (Ibuprofen, Naproxen, Toradol): Can interfere with implantation in early pregnancy and cause complications later.
  • Ergotamines (Cafergot): Strong vasoconstrictors that may harm the developing baby.
  • Certain Preventative Medications (Depakote, Topamax): Known to cause birth defects and should be discontinued before pregnancy.

Alternative and Natural Approaches

For those who prefer a non-medication approach, these strategies can help prevent and manage migraine attacks during pregnancy:

  • Supplements: Riboflavin (B2) and Magnesium are safe and effective options.
  • Lifestyle Adjustments: Prioritize hydration, proper sleep, and regular meals to prevent migraine triggers.
  • Acupuncture & Physical Therapy: Can provide relief for some women without the need for medication.
  • Non-invasive neuromodulators

What to Do If You’re Planning a Pregnancy

If you are currently using prescription migraine preventatives and plan to conceive, consult your health care provider about tapering off medications that might not be safe. Some treatments, such as CGRP monoclonal antibodies (Aimovig, Ajovy, Emgality), have long half-lives and should be stopped 5-6 months before attempting to conceive. Shorter-acting alternatives like Qulipta may be considered during this transition period.

Final Thoughts

Pregnancy doesn’t mean you have to endure migraine attacks without relief. Numerous treatment options, both pharmaceutical and natural, are available to help manage your symptoms safely. Always consult a healthcare provider or headache specialist to develop a personalized treatment plan that works best for you and your baby.

If you need guidance on managing migraine attacks during pregnancy, Haven Headache is here to support you with expert-led care. Contact us today to explore your treatment options!

Disclaimer: The information provided in this article is for educational purposes only and should not be considered medical advice. Always consult with your healthcare provider before starting or stopping any medication or treatment plan. If you need professional guidance, book an appointment with Haven Headache for personalized care.

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